How law enforcement plans to keep visitors safe at Pasadena’s Rose Parade and Rose BowlDo you remember when began? Maybe not, but almost every modern TV bingewatcher remembers when landed on Netflix as a holiday surprise that after the show withered on the Lifetime vine. Netflix then took the serial-killing ball and ran with it, taking Joe from New York to Los Angeles to Suburban Hell to England and now back again to Manhattan. Hopefully, Joe Goldberg will get some of his edge back during the fifth and final season that has been in the works for over a year. During his run, Penn Badgley has been forthright about how disturbed he feels about his stalker character, and around the fourth season he about certain promotional aspects of the series, but has also thrown himself headlong into his character’s mirror-to-society characteristics to chilling effect. Let’s piece together some evidence about how it might end for Netflix’s thirsted-after killer. Plot Dancing around this possibility seems pointless, so let’s rip off the bandaid: is Joe Goldberg going to die? That feels destined to occur, although Netflix of course hasn’t taken a stance to avoid spoiling what happens. What does seem telling is that Joe Goldberg, who will return to his bookshop management gig, will be (as revealed by Badgley in ) visited by his past in a vengeance. Badgley suggested that anyone, including John Stamos’ Dr. Nicky, could be back to cause trouble. And since we know that Nicky got framed for some of Joe’s misdeeds, the disgraced therapist has a damn fine reason to bring Joe down if possible. Furthermore, a prominent detective character will surface and be portrayed by ‘s Nava Mau. In other words, going “home” might have been the biggest mistake that Joe has ever made. Netflix has of Joe striding through the Upper East Side near the bookshop that he used to own. Various photos on the internet show that he at least visited Mooney’s bookshop, which was where most of his first-season homicidal behavior occurred, although we do not know whether any evidence remains in the basement. Nor do we know if he reopens Mooney’s or creates a new business elsewhere in Manhattan. To do so seems like suicide, so is Joe simply exhausted of running from reality? Perhaps he wants to be caught. After all, there have been too many stressed-out moments in his past, going back to when he killed Peach Salinger. On a production note, series co-creator Sera Gamble left her showrunning gig this season, and in her place will be writers Michael Foley and Justin W. Lo. And to promote this final season, Badgley posted that took on the “very demure, very mindful” meme: “Playing a romantic icon for five seasons, I’m very modest, I’m very mindful.” Don’t turn on this season and anticipate any , however, because that ship has sailed. Cast Badgley will wrap up his most notorious turn yet, even more so than his warm-up role in . This season, he will be accompanied by an array of new potential victims, including Madeline Brewer’s Bronte, an employee of his bookstore and a playwright who cannot possibly be using her birth name. Joe’s latest wife, Charlotte Ritchie’s Kate, has stuck around, and Griffin Matthews will portray Kate’s socially outcast brother. Kate also has identical twin sisters, both ruthless and manipulative and picked up by Anna Camp, who might not be buying Joe’s BS. And will portray a detective, so watch out, Joe. As is customary, expect Badgley to be haunted by Elizabeth Lail’s Beck and Victoria Pedretti’s Love, and perhaps we will also see Tati Gabrielle’s Marienne and Ambyr Childers’ Candace to give him a final kick as the series ends. Jenna Ortega, who previously portrayed Ellie Alves, has expressed interest in returning, although her busy schedule would make that possibility a long shot, but John Stamos’ Dr. Nicky remains alive and vengeful [cough]. Release Date Since 2024 has nearly come and gone, bet on 2025. Trailer Netflix has been surprisingly quiet on this front, but here’s a refresher on why Joe is not the guy for “you.”CleanSpark, Inc. Announces Proposed Private Offering of $550 Million of Convertible Notes
The Shiromani Akali Dal (SAD) on Friday condemned the Aam Aadmi Party (AAP) government’s proposal to allow private builders to buy back land reserved for housing economically weaker sections (EWS). In a statement here, SAD vice-president Daljit Singh Cheema demanded a high-level probe into the proposal, stating that it smacked of corruption. He appealed to the state cabinet to not approve the proposal, saying that it would be a death blow to the aspirations of the weaker sections to own houses under the EWS scheme. “This proposal to auction land reserved for building EWS houses is a clear message to the ‘Aam Aadmi’ that they should stop dreaming of owning a small shelter near high-end flats,” he added. Asserting that the proposal would not pass legal scrutiny, the SAD leader said that private builders were given additional benefits to offset the losses caused to them for building houses under the EWS scheme. “The government also derived political capital by publicising the scheme. Now, when the residential areas have been developed and sold at huge profits, a plan is afoot to sell this land back to private developers and throw the weaker sections out of the scheme and force them to accept alternative accommodation in far off undeveloped areas,” he said.
Tennessee 32, Houston 27
Business News | Government Prioritising Improved Connectivity Across State: Bihar Chief SecretaryTRAGIC Sara Sharif excitedly told her grandad about a planned trip with her siblings just hours before she was killed. The ten-year -old also told him she was looking forward to visiting him in Pakistan so they could explore his village. 3 Sara Sharif excitedly told her grandad about a planned trip with her siblings just hours before she was killed Credit: Simon Jones - Commissioned by The Sun 3 Urfan Sharif and partner Beinash Batool were convicted of Sara's murder Credit: PA Grandad Muhammad, speaking before his son Urfan , who is Sara’s father, her stepmum Beinash Batool and her uncle Faisal Malik were convicted, said he chatted with her on a video call on the day she died. He told The Sun: “She was having dinner on the dining table. "I can’t believe she was brutally beaten. “She talked about going for a trip with her siblings in coming days and she said she will visit Pakistan and meet me and want to explore the village again.” read more on uk news SARA FAILED From burn marks to teachers spotting bruises - 15 missed chances to save Sharif On Wednesday, father-of-seven Muhammad, 68, collapsed and had to be taken to hospital when the three were found guilty . Urfan, 43, and partner Batool, 30, were convicted of murder and Urfan’s brother Malik, 29, of allowing her death. Sara had suffered years of abuse before being beaten to death at her home in Woking, Surrey, last year. Urfan, who divorced Sara’s mum Olga Domin in 2017, Batool and Malik then fled to Pakistan, turning up at the family home in Jhelum. Most read in The Sun FAIR CARNAGE Horror as Birmingham fairground ride 'collapses' with several people injured STAYING POSITIVE Max George to undergo major heart surgery after terrifying health scare ALL CHANGE Another Rangers executive quits club just a week after key role at club's AGM NEWBORN JOY Huge Scots DJ becomes dad as he reveals baby boy in emotional social media post Ex-army officer Muhammad told The Sun: “ The death of Sara was the saddest moment of my life. “When Urfan suddenly reached our family home and told me Sara is no more, I did not believe his words. Moment armed police storm plane at Gatwick to arrest Sara Sharif's dad & stepmum - as pair found GUILTY of murder "I was expecting Sara to come with them and give us a surprise. "I yelled and cried loudly and shouted at them. "It was a heartbreaking moment for me. “I was not aware of the level of torture and abuse but the stepmum Batool’s behaviour was not good.” She talked about going for a trip with her siblings in coming days and she said she will visit Pakistan and meet me and want to explore the village again Grandad Muhammad Meanwhile, another of his sons, Urfan’ s brother, Imran, is standing by the killer, insisting that he is innocent. He said: “He would never harm his own daughter. “We plan to consult our legal team and push our brother Urfan to appeal this verdict. "This decision has deeply affected us and left our family in deep sorrow. Read more on the Scottish Sun WARMING UP Scots set for 21C swing as temperature rise to bring an end to sub zero freeze HOT BUY Shoppers race to Primark for fleecy £14 hoodie will keep you cosy on frosty days “We are determined to fight this unjust verdict with our legal team and seek justice. "This ruling has shattered our family, leaving us devastated and deeply anguished.” 3 Sara’s mum Olga Domin Credit: Simon Jones - Commissioned by The Sun
President-elect Donald Trump’s incoming administration could try to remove fluoride from drinking water, according to Robert F. Kennedy Jr. Kennedy, who was tapped last week by Trump to lead the Department of Health and Human Services, called fluoride an “industrial waste” and linked it to cancer and other diseases and disorders while campaigning for Trump. “On January 20, the Trump White House will advise all U.S. water systems to remove fluoride from public water. Fluoride is an industrial waste associated with arthritis, bone fractures, bone cancer, IQ loss, neurodevelopmental disorders, and thyroid disease,” Kennedy wrote Nov. 2 on X. Kennedy linked to a video from an attorney who recently successfully sued the Environmental Protection Agency to take additional measures to regulate fluoride in drinking water. Kennedy, who has long advocated ending water fluoridation, persisted with his pledge following Trump’s election win. When asked before the election whether his administration would remove fluoride from drinking water, Trump said, “Well, I haven’t talked to him about it yet, but it sounds OK to me. You know it’s possible.” Kennedy is an influential vaccine skeptic whose campaign of conspiracy theories earned PolitiFact’s 2023 “Lie of the Year.” Longtime research has found that adding fluoride to U.S. drinking water is a safe way to boost children’s oral health. Since 2015, the recommended level in the U.S. has been 0.7 milligrams per liter. Public health organizations, including the American Dental Association, the American Academy of Pediatrics, and the Centers for Disease Control and Prevention, support the practice. Recent studies, however, have shown possible links between fluoride and bone problems and children’s IQs, particularly when fluoride is above the U.S. recommended levels. “There is evidence that fluoride exposure has been associated with the diseases [and] disorders that RFK listed, but with caveats,” said Ashley Malin, who is an assistant professor in the University of Florida’s Epidemiology Department and has studied fluoride’s effects in pregnant women. Malin referred to studies showing that higher fluoride exposure, particularly during pregnancy, is associated with reduced child IQ, and that prenatal exposure also is linked to decreased intellectual functioning and executive function. For high exposure in pregnancy, the studies showed symptoms associated with other neurobehavioral issues, such as attention-deficit/hyperactivity disorder. However, many of these studies took place in countries other than the U.S. and looked at fluoride in drinking water at sometimes twice the United States’ recommended level. Also, some of the other ailments that Kennedy listed, such as an association with bone cancer, have less robust evidence and need more study. “Aside from fluoride’s impacts on neurodevelopment, I think that there is more that we don’t know about health effects of low-level fluoride exposure than what we do know, particularly for adult health outcomes,” Malin said. David Bellinger, a Harvard Medical School neurology professor and professor in Harvard School of Public Health’s Environmental Health Department, said the risk-benefit calculation of added fluoride differs depending on whether typical fluoride exposure levels cause health problems, or if problems occur only when recommended levels are exceeded. “In toxicology, ‘the dose makes the poison’ is a long-standing principle,” he said. “So a general statement that fluoride is associated with diseases X, Y, and Z is not very helpful unless the dose that might be responsible is specified.” PolitiFact contacted Kennedy through his Children’s Health Defense organization but received no reply. The organization sued PolitiFact and Meta related to a 2020 fact check. That lawsuit was dismissed by a federal court. The dismissal was upheld on appeal, and the case is pending a possible appeal to the U.S. Supreme Court. What is fluoride and what are its benefits? Fluoride is a mineral naturally occurring in soil, water and some foods that helps prevent tooth decay and cavities. It strengthens tooth enamel that acid from bacteria, plaque and sugar can wear away. Water fluoridation has been happening in the U.S. since 1945. The federal Public Health Service first recommended fluoridation of tap water in 1962, but the decision still lies with states and municipalities. Around 72 percent of the U.S. population, or about 209 million people, had access to fluoridated water in 2022, the CDC reported. Fluoride also has been added to oral care products such as toothpaste and mouth rinse. In 2015, U.S. health officials lowered the recommended amount of fluoride in drinking water to 0.7 milligrams per liter, saying a higher level was less necessary given other sources of fluoride, and that the lowered amount would still help protect teeth without staining them. Pediatric dentists note that applying fluoride with toothpaste and rinses is beneficial, but small amounts circulating in the body via water consumption helps younger children who still have their baby teeth, because it can benefit the developing permanent teeth. The American Dental Association says studies have shown that fluoride in community water systems prevents at least 25 percent of tooth decay in children and adults and that “for more than 75 years, the best scientific evidence has consistently shown that fluoridation is safe and effective.” The association says on its website: “It’s similar to fortifying other foods and beverages — for example, fortifying salt with iodine, milk with vitamin D, orange juice with calcium, and bread with folic acid.” According to the CDC, health experts and scientists from the U.S. and other countries have so far “not found convincing scientific evidence linking community water fluoridation with any potential adverse health effect or systemic disorder such as an increased risk for cancer, Down syndrome, heart disease, osteoporosis and bone fracture, immune disorders, low intelligence, renal disorders, Alzheimer’s disease, or allergic reactions.” The agency says risks of water fluoridation are limited to dental fluorosis, which can alter dental enamel and cause white flecks, spots, lines, or brown stains on the teeth when too much fluoride is consumed. Do studies show fluoride posing any other risks? Some studies have said that excess fluoride exposure, often at higher levels than the recommended U.S. limit, can harm infants’ and young children’s developing brains and that higher levels of fluoride exposure during pregnancy were associated with declines in children’s IQs. A study published in May that Malin led with University of Southern California and Indiana University researchers suggested that fluoride exposure during pregnancy was linked to an increased risk of childhood neurobehavioral problems and said more studies were “urgently needed to understand and mitigate the impacts in the entire U.S. population.” Experts noted prenatal fluoride exposure is most strongly linked to children’s IQ loss, and said timing of fluoride consumption might need to be considered when making recommendations. A federal review of dozens of studies published in August by the Department of Health and Human Services’ National Toxicology Program concluded that higher levels of fluoride exposure were linked to lower IQs in children. But the report was based primarily on studies in countries such as Canada, China, India, Iran, Mexico, and Pakistan and involved fluoride levels at or above 1.5 milligrams per liter, twice the recommended U.S. limit. The authors said more research is needed to understand whether lower exposure has any adverse effects. In the report, researchers said they found no evidence that fluoride exposure adversely affected adult cognition. Bellinger, of Harvard, pointed to the review as an example of how the amount of fluoride matters. He noted how researchers concluded that a very small percentage of people in the U.S. are exposed to levels that correlate with IQ loss. “Second, the fact that there are now multiple pathways of exposure to fluoride besides fluoridated water (toothpaste and other dental products, etc.) makes it really difficult to attribute a particular adverse effect to the fluoride added to the water,” he wrote via email. “It is the cumulative exposure from all sources that contribute to any adverse health effects.” In September, a federal judge ordered the Environmental Protection Agency to further regulate fluoride in drinking water because of the potential risk that higher levels could affect children’s intellectual development. U.S. District Judge Edward Chen wrote that the court’s finding didn’t “conclude with certainty that fluoridated water is injurious to public health,” saying it’s unclear whether the amount of fluoride typically added to water is causing children’s IQs to drop. But he wrote that there was enough risk to warrant investigation and that the EPA must act to further regulate it. The ruling did not specify what actions the agency should take, and the EPA is reviewing the decision. After the ruling, the American Association of Pediatrics issued a statement that fluoride in drinking water is safe for children and said the policy is based on a robust foundation of evidence. Besides dental fluorosis, experts say that fluoride exposure over many years above the U.S. recommended amount can cause skeletal fluorosis, a rare condition that causes weaker bones, stiffness and joint pain. Although the Public Health Service recommends a fluoride concentration of 0.7 milligrams per liter for community water systems, the EPA, under the Safe Drinking Water Act, sets enforceable standards for drinking-water quality. Currently, to prevent skeletal fluorosis, the EPA requires that water systems not exceed 4 milligrams of fluoride per liter of water. Malin said she and her research team are investigating a potential link between fluoride and bone fractures. She said that although several studies have found high fluoride exposure associated with increased risk of bone fractures, and some have linked fluoride with thyroid disease, rigorous, U.S.-based studies haven’t been done. The CDC concluded that recent research found no link between cancer risk and high levels of fluoride in drinking water. The American Cancer Society reviewed a possible link between water fluoridation and cancer risk. An organization spokesperson pointed PolitiFact to its review and said it has no data showing a definitive answer. KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs of KFF — the independent source for health policy research, polling and journalism.
Pittsburgh Steelers vs. Philadelphia Eagles: This expert prediction includes our best bet of the game. AP Pat Sharyon | Special Correspondent The Pittsburgh Steelers will face in-state rival and fellow Super Bowl contender Philadelphia Eagles at Lincoln Financial Field on Sunday at 4:25 p.m. EST. While Russell Wilson and the Steelers have been the surprise of the 2024 NFL season, outpacing all expectations with complementary football on both sides of the ball, the Eagles’ success has come as a shock to no one. Having won nine straight contests heading into Sunday’s massive showdown, The Birds look like the team to beat in the NFC (sorry, Lions fans). The experts agree: our best bet for this game is Eagles moneyline (-225). Ahead of this clash of the Keystone State, the data analysts at Dimers.com have simulated the game 10,000 times, and then compared these results to current NFL betting odds to inform the data-driven betting preview provided to you below. This preview includes Dimers’ best bets and predicted scoreline for Pittsburgh Steelers vs. Philadelphia Eagles. To unlock Dimers’ full suite of data-driven betting insights, which includes daily props, trends, and parlays, sign up for Dimers Pro with promo code SYRACUSE10 , which will save you 10% off your first subscription payment. Bet365 is now operating in the state of Pennsylvania, making this the perfect chance for both Steelers and Eagles fans to claim huge betting bonuses with our brand new exclusive bet365 bonus code “SYRACUSE”, while sports fans in New York State can take full advantage of our NBA League Pass FanDuel promo code. Additionally, bettors are encouraged to check out this exclusive promo offer from DraftKings and BetMGM. Steelers vs. Eagles betting preview Explore the interactive widget below to discover the current spread, total, and moneyline odds and probabilities for the Steelers-Eagles game at Lincoln Financial Field. This prediction and best bet for Sunday’s NFL matchup between the Steelers and Eagles is from Dimers.com , a trusted source for sports betting predictions. Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country. Game details The key information you need before the Steelers vs. Eagles NFL game. Teams: Pittsburgh Steelers vs. Philadelphia Eagles Date: Sunday, December 15, 2024 Kickoff: 4:25 p.m. EST Location: Lincoln Financial Field NFL standings: Current NFL division standings NFL injuries: Check the latest updates to the official NFL injury report Odds Odds for the key markets in the Steelers-Eagles NFL clash. Spread: Steelers +5.5 (-110), Eagles -5.5 (-108) Moneyline: Steelers +205, Eagles -225 Total: Over/Under 42.5 (-115/-105) The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change. Expert prediction: Steelers vs. Eagles Leveraging cutting-edge data analysis and advanced algorithms, the experts at Dimers have executed 10,000 simulations of Sunday’s Steelers vs. Eagles matchup. According to Dimers’ famous predictive analytics model, the Eagles are more likely to beat the Steelers at Lincoln Financial Field. This prediction is based on the model giving the Eagles a 71% chance of winning the game. Furthermore, Dimers predicts that the bookmakers have got it right and the Steelers and Eagles each have a 50% chance of covering the spread, while the 42.5-point over/under has a 51% chance of going over. As always, these predictions and probabilities are correct at the time of publication but are subject to potential changes. Steelers vs. Eagles best bet Our top pick for the Steelers vs. Eagles Week 15 NFL matchup is to bet on the Eagles moneyline (-225) . This expert betting advice is based on cutting-edge modeling and valuable wagering intelligence, designed to bring you the best possible plays. Score prediction for Steelers vs. Eagles Dimers’ projected final score for the Pittsburgh vs. Philadelphia game on Sunday has the Eagles winning 24-18. This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome. NFL player props: Sunday NFL player props are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome. This article features the most likely first and anytime touchdown scorers for the Steelers and Eagles, as well as projected player stats. Pittsburgh Steelers First touchdown scorer predictions Najee Harris: 7.9% probability Jaylen Warren: 6.9% probability Mike Williams: 5.2% probability Anytime touchdown predictions Najee Harris: 33.5% probability Jaylen Warren: 31.1% probability Mike Williams: 23.0% probability Projected box score leaders QB passing yards: Russell Wilson , 192 yards Receiving yards: Mike Williams , 39 yards Rushing yards: Najee Harris , 59 yards Philadelphia Eagles First touchdown scorer predictions Saquon Barkley: 16.8% probability Jalen Hurts: 13.0% probability A.J. Brown: 8.0% probability Anytime touchdown predictions Saquon Barkley: 60.3% probability Jalen Hurts: 49.9% probability A.J. Brown: 32.9% probability Projected box score leaders QB passing yards: Jalen Hurts , 220 yards Receiving yards: A.J. Brown , 56 yards Rushing yards: Saquon Barkley , 103 yards NFL Week 15: Steelers vs. Eagles Get ready for Sunday’s game between the Steelers and Eagles in Week 15 of the NFL season at Lincoln Financial Field, which is scheduled to start at 4:25 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are derived from 10,000 data-driven simulations of the Steelers vs. Eagles game, and they are correct at the time of publishing to help you make better decisions when placing bets at online sportsbooks . Please note that when engaging in online betting, it is important to exercise responsible gambling practices and seek reputable sources for accurate and up-to-date information. 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COPENHAGEN, Denmark, Dec. 12, 2024 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq: ASND) today announced that the U.S. Food & Drug Administration (FDA) has accepted for review its supplemental Biologics License Application (sBLA) in adult growth hormone deficiency (GHD) for TransCon hGH (lonapegsomatropin-tcgd; marketed as SKYTROFA ® for pediatric GHD). The FDA set a Prescription Drug User Fee Act (PDUFA) goal date of July 27, 2025. “This marks another step towards achieving our objective to expand SKYTROFA’s label beyond pediatric GHD and expand its reach to address new groups of patients,” said Jan Mikkelsen, Ascendis Pharma’s President and Chief Executive Officer. “Adult GHD is an undertreated condition associated with significant comorbidities and higher annual healthcare costs compared to the 5-10% of patients who receive treatment, indicative of the high unmet need.” The sBLA submission is based on results from foresiGHt, a Phase 3 randomized, parallel-arm, placebo-controlled (double-blind) and active-controlled (open-label) trial that compared the efficacy and safety of weekly TransCon hGH with weekly placebo and daily human growth hormone (hGH) in adults with GHD. The trial evaluated 259 adults with GHD aged 23 to 80 years old, randomized 1:1:1, titrated to receive a target fixed dose of TransCon hGH, placebo, or daily hGH based on age and oral estrogen intake with approximately equivalent hGH mg/week for TransCon hGH and daily hGH. TransCon hGH demonstrated superiority on its primary efficacy and key secondary efficacy endpoints at Week 38, with TransCon hGH-treated participants showing a statistically significant reduction from baseline in trunk fat and increase in total body lean mass at Week 38 compared to placebo. In the trial, TransCon hGH was generally safe and well tolerated, with no discontinuations related to study drug and with comparable safety and tolerability to daily hGH treatment. About Adult Growth Hormone Deficiency Growth hormone plays an essential role in the health of children and adults, promoting normal growth in children and maintenance of normal body composition and cardiometabolic health throughout adulthood. In adults, growth hormone boosts protein production, promotes fat utilization, enhances muscle mass, and helps regulate blood sugar levels. Adult GHD is a condition in which an individual’s body does not produce enough growth hormone. Symptoms and morbidity can include central obesity, metabolic syndrome, decreased bone density, alterations in lipid profile and markers of cardiovascular risk, fatigue, general weakness, lack of muscle tone, and psychological symptoms such as cognitive impairment, social isolation, lack of motivation, and depression. 1 About Ascendis Pharma A/S Ascendis Pharma is applying its innovative TransCon technology platform to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients’ lives. Guided by its core values of Patients, Science, and Passion, Ascendis uses its TransCon technologies to create new and potentially best-in-class therapies. Ascendis is headquartered in Copenhagen, Denmark and has additional facilities in Europe and the United States. Please visit ascendispharma.com to learn more. Forward-Looking Statements This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis’ future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) the PDUFA goal date for SKYTROFA, (ii) Ascendis’ objective to expand SKYTROFA’s label and reach to address new groups of patients, (iii) Ascendis’ ability to apply its TransCon technology platform to build a leading, fully integrated biopharma company, and (iv) Ascendis’ use of its TransCon technologies to create new and potentially best-in-class therapies. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations, and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including the following: dependence on third party manufacturers, distributors and service providers for Ascendis’ products and product candidates; unforeseen safety or efficacy results in Ascendis’ development programs or on-market products; unforeseen expenses related to commercialization of any approved Ascendis products; unforeseen expenses related to Ascendis’ development programs; unforeseen selling, general and administrative expenses, other research and development expenses and Ascendis’ business generally; delays in the development of its programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; Ascendis’ ability to obtain additional funding, if needed, to support its business activities; the impact of international economic, political, legal, compliance, social and business factors. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis’ business in general, see Ascendis’ prospectus supplement filed on September 20, 2024 and Ascendis’ current and future reports filed with, or submitted to, the U.S. Securities and Exchange Commission (SEC), including its Annual Report on Form 20-F filed with the SEC on February 7, 2024. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward-looking statements, except as required by law. Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo, TransCon, and SKYTROFA ® , are trademarks owned by the Ascendis Pharma group. © December 2024 Ascendis Pharma A/S. 1 . Hoffman AR, Mathison T, Andrews D, Murray K, Kelepouris N, Fleseriu M. Adult Growth Hormone Deficiency: Diagnostic and Treatment Journeys From the Patients' Perspective. J Endocr Soc. 2022;6(7):bvac077. Published 2022 May 12. doi:10.1210/jendso/bvac0772025 Social Security benefits will change from January first for millions of people
Trump has promised again to release the last JFK files. But experts say don’t expect big revelationsEssential Links Top 20 All-time scorers Players | Title contenders Featured Games Saturday, Dec. 21 BCSL Maple Shade vs. Westampton Tech at Jimmy V Classic @Cherokee HS, 10am Camden Tech at Pennsauken Tech, 10:30am Delran at Audubon, 11:30am Camden Catholic at Cinnaminson, 7pm Big North Ridgewood at Passaic Tech, 10am Teaneck vs. Pioneer Academy at Paterson Eastside HS, 11am Tenafly at Dwight-Morrow, 11:30am Ramapo vs. Bergen Tech at Ramapo HS, 12pm Old Tappan at Paramus, 12pm Lakeland at Mahwah, 12pm Pascack Hills at Ridgefield Park, 1pm River Dell at Pascack Valley, 1pm Paramus Catholic at Ramsey, 1pm Northern Highlands at Union City, 1pm Fort Lee at Passaic Valley, 1pm Passaic at DePaul, 1pm West Milford at Westwood, 1pm Clifton at Wayne Valley, 1pm Dumont at Indian Hills, 1pm Cliffside Park at Bergenfield, 1pm Demarest at St. Joseph (Mont.), 1pm Hackensack at Paterson Eastside, 2pm Don Bosco Prep vs. Devon Prep (PA) at Archbishop Wood (PA), 3pm Wayne Hills vs. Paterson Kennedy at Paterson Eastside HS, 3:30pm Bergen Catholic vs. Father Judge (PA) at Archbishop Wood High School (PA), 6pm Cape-Atlantic Cumberland vs. Bridgeton at Bridgeton High School, 10am Overbrook at Mainland, 11:30am Gateway at Cape May Tech, 11:30am Pleasantville vs. St. Joseph (Hamm.) at Ocean City High School Tip Off Classic, 12pm Timber Creek vs. Middle Township at Cherokee High School, 4:30pm Paul VI at Atlantic City, 5:15pm Vineland vs. Millville at Millville High School, 5:30pm Camden Eastside at St. Augustine, 7pm Colonial Delran at Audubon, 11:30am Gateway at Cape May Tech, 11:30am Cherry Hill West at Sterling, 1pm Haddon Township at Triton, 1pm Haddonfield vs. Lenape at Cherokee High School, 5:30pm Haddon Heights at Washington Township, 7pm CVC Middletown South vs. West Windsor-Plainsboro South at Hightstown High School, 10am Nottingham at New Egypt, 11:30am Princeton Day at Episcopal (PA), 11:30am Lawrence at Carteret, 1pm West Windsor-Plainsboro North vs. Jackson Memorial at Hightstown High School Showcase, 2pm Manalapan at Steinert, 2:30pm Shore vs. Princeton at Hightstown High School, 4pm Marlboro vs. Notre Dame at Hightstown HS, 5:30pm Hopewell Valley at Freehold Borough, 5:30pm Trenton vs. Morris Catholic at Weequahic HS, 5:30pm GMC North Brunswick at Perth Amboy, 11:30am Edison at South Brunswick, 11:30am Dunellen at Spotswood, 11:30am Pilgrim Academy vs. Timothy Christian at Timothy Christian School, 12:30pm J.P. Stevens at Oratory, 1pm Lawrence at Carteret, 1pm Wardlaw-Hartridge at Johnson, 1pm East Brunswick at Woodbridge, 1pm Piscataway Magnet at Metuchen, 1:30pm Calvary Christian (Old Bridge) at South Amboy, 2pm Bridgewater-Raritan at North Plainfield, 4pm CSI/McCown (NY) vs. Sayreville at South Amboy High School, 4pm Montgomery vs. St. Joseph (Met.) at Friends of South Amboy Charity Showcase, 8pm HCIAL St. Peter's Prep at Roman Catholic (PA), TBA Newark Global Studies at McNair, 11:30am Kearny at Memorial, 12pm Hoboken at Ridge, 1pm Northern Highlands at Union City, 1pm Miami Senior (FL) at Hudson Catholic, 1pm Ferris vs. Dickinson at Dickinson HS, 1pm NJAC Madison vs. Phillipsburg at Hackettstown HS, 11am American Christian at High Point, 11am Roselle Park at Hanover Park, 12pm North Warren at Notre Dame (E. Stroudsburg) (PA), 12pm Dover at Wallkill Valley, 12:30pm West Morris vs. North Hunterdon at Hackettstown HS, 12:30pm Rutgers Prep at Delbarton, 1pm Warren Hills at Vernon, 1pm Chatham at Montville, 1pm Jefferson at Morris Hills, 1pm Mountain Lakes at Parsippany Hills, 1pm Bergen Charter at Morristown, 1pm Kinnelon at Kittatinny, 1pm Pope John vs. Bloomfield at Bloomfield High School, 1pm Bernards at Morristown-Beard, 2pm Randolph at Hackettstown, 3:30pm Trenton vs. Morris Catholic at Weequahic HS, 5:30pm Whippany Park at Mendham, 6pm NJIC Paterson Charter at Saddle Brook, 10am Elmwood Park at Lodi, 10am Dwight-Englewood at New Milford, 10am Lyndhurst at Rutherford, 12pm Bogota at Leonia, 12pm Hawthorne Christian at Pompton Lakes, 12pm Park Ridge at Saddle River Day, 1pm Waldwick at Midland Park, 1pm Wallington at Wood-Ridge, 1pm Secaucus at Weehawken, 1pm Butler at Glen Rock, 1pm Emerson Boro at Cresskill, 1pm Hawthorne at Eastern Christian, 1pm Harrison at North Arlington, 1pm Becton at Hasbrouck Heights, 1pm Palisades Park at Ridgefield, 7pm Olympic Clearview at Rancocas Valley, 10am Williamstown vs. Winslow at Jimmy V Classic/Cherokee High School, 11:30am Bishop Guilfoyle (PA) vs. Bishop Eustace at Archbishop Wood - Diane Mosco Showcase, 12pm Cherry Hill West at Sterling, 1pm Delsea at Cherry Hill East, 1:30pm Gloucester Catholic at Cherokee, 2:30pm Toms River North vs. Eastern at Cherokee HS, 4pm Paul VI at Atlantic City, 5:15pm Haddonfield vs. Lenape at Cherokee High School, 5:30pm Kingsway at Moorestown, 5:30pm Camden Catholic at Cinnaminson, 7pm Camden Eastside at St. Augustine, 7pm SEC Caldwell at Orange, 10am Irvington at West Essex, 11:30am West Caldwell Tech at Nutley, 11:30am West Orange at Cedar Grove, 1pm American History at Barringer, 1pm Montclair at Science Park, 1pm North Star Academy at Belleville, 1pm Glen Ridge at Eagle Academy, 1pm Seton Hall Prep at Columbia, 1pm Technology at West Side, 1pm Newark Tech at East Orange, 1pm Weequahic at University, 1pm Shabazz at Newark Lab, 1pm Pope John vs. Bloomfield at Bloomfield High School, 1pm Newark Academy at Bard, 1:30pm Millburn at Livingston, 3pm Gill St. Bernard's vs. St. Benedict's at Weequahic HS, 4pm Brooklyn Collegiate (NY) vs. Arts at Weequahic HS, 7pm Shore Middletown South vs. West Windsor-Plainsboro South at Hightstown High School, 10am Raritan vs. Wall at Wall HS, 11:30am Freehold Township at Red Bank Catholic, 11:30am Long Branch at Point Pleasant Beach, 11:30am Nottingham at New Egypt, 11:30am Manasquan at Rumson-Fair Haven, 1pm Colts Neck at Neptune, 1pm Holmdel at Christian Brothers, 1pm West Windsor-Plainsboro North vs. Jackson Memorial at Hightstown High School Showcase, 2pm Manalapan at Steinert, 2:30pm Shore vs. Princeton at Hightstown High School, 4pm Toms River North vs. Eastern at Cherokee HS, 4pm Marlboro vs. Notre Dame at Hightstown HS, 5:30pm Hopewell Valley at Freehold Borough, 5:30pm Skyland Madison vs. Phillipsburg at Hackettstown HS, 11am West Morris vs. North Hunterdon at Hackettstown HS, 12:30pm Hoboken at Ridge, 1pm Rutgers Prep at Delbarton, 1pm Warren Hills at Vernon, 1pm Dayton at South Hunterdon, 1pm Immaculata at Delaware Valley, 1pm Hunterdon Central at Hillsborough, 1pm Bernards at Morristown-Beard, 2pm Bridgewater-Raritan at North Plainfield, 4pm Gill St. Bernard's vs. St. Benedict's at Weequahic HS, 4pm Montgomery vs. St. Joseph (Met.) at Friends of South Amboy Charity Showcase, 8pm Tri-County Cumberland vs. Bridgeton at Bridgeton High School, 10am Clearview at Rancocas Valley, 10am Williamstown vs. Winslow at Jimmy V Classic/Cherokee High School, 11:30am Overbrook at Mainland, 11:30am Haddon Township at Triton, 1pm Delsea at Cherry Hill East, 1:30pm Gloucester Catholic at Cherokee, 2:30pm Timber Creek vs. Middle Township at Cherokee High School, 4:30pm Kingsway at Moorestown, 5:30pm Haddon Heights at Washington Township, 7pm UCC Roselle Park at Hanover Park, 12pm Union Catholic at Westfield, 12pm Union at Roselle Catholic, 1pm Brearley at Roselle, 1pm Cranford at Summit, 1pm Dayton at South Hunterdon, 1pm New Providence at Hillside, 1pm J.P. Stevens at Oratory, 1pm Wardlaw-Hartridge at Johnson, 1pm Rahway at Scotch Plains-Fanwood, 6:30pm Elizabeth at Linden, 7pm
Abpro Holdings Celebrates Closing of Business Combination with Nasdaq Bell RingingTHE Cavite State University (CvSU) in Indang, Cavite hosted the Accrediting Agency of Chartered Colleges and Universities in the Philippines Inc. (Aaccup) Bayanihan 2024 held at CvSU International Convention Center on Nov. 6 to 8, 2024, According to CvSU Vice President for Research and Extension Melbourne Talactac, the Aaccup Bayanihan 2024 national conference was participated by university presidents and Aaccup accreditors of various state universities and colleges (SUCs) from different parts of the country. Register to read this story and more for free . Signing up for an account helps us improve your browsing experience. OR See our subscription options.
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Varanasi, Dec 21 (IANS): The United Nations (UN) has declared December 21 as Meditation Day. Reactions from across various sections of society have been pouring in following this announcement. The people of Varanasi have also welcomed this declaration by the United Nations. The people of Varanasi believe that this initiative will not only promote the religious and cultural identity of Varanasi but will also highlight the importance of meditation and mental peace worldwide. This step, honouring Varanasi's traditions and spiritual heritage, is seen as a move in a positive direction. Advocate Anurag Pandey congratulated the United Nations for this initiative, calling it a wonderful step for health, similar to the celebration of Yoga Day. He believes that this announcement will be very beneficial and hopes that more people will be drawn to this practice. Advocate Avnish Rai expressed that this is a moment of great pride for India. He mentioned that India's traditions are being recognised worldwide, which is a matter of pride for the country and its people. He also pointed out the recent shift in people's daily routines, with more individuals adopting yoga and meditation, leading to a broader acceptance of spiritual traditions. Rajeev Rai said this is a very positive step. After yoga, this is another excellent initiative for health. He further stated that declaring December 21 as Meditation Day is a remarkable move by the United Nations. Pawan Singh also praised this declaration, expressing confidence that it will yield positive results in the future. On this announcement by the United Nations, Prime Minister Narendra Modi wrote on the X: "Today, on World Meditation Day, I call upon everyone to make meditation a part of their daily lives and experience its transformative potential. Meditation is a powerful way to bring peace and harmony to one’s life, as well as to our society and planet. In the age of technology, Apps and guided videos can be valuable tools to help incorporate meditation into our routines."‘I Agree, But...’: Ranbir Kapoor Has THIS To Say Over Constant Backlash About ‘Animal’, Days After Javed Akhtar Criticised It (Watch Video)
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